Research in the Hohenlohe Lab centers on developing sophisticated
theory and analytical tools and studying a range of natural and
experimental systems to address a wide range of questions in the
emerging field of evolutionary genomics.
Genomic Architecture of Evolution
The genetic basis of complex, multivariate phenotypes depends on
the distribution and interactions of many loci across the
genome. Evolutionary forces shape this genomic architecture
of phenotypic variation, and genomic architecture in turn
constrains and bends the responses to natural selection and the
trajectories of diversification. Modern sequencing
technology now allows us to take an empirical genome-scale view of
evolution in a myriad of taxa.
Our research addresses a range of related questions: What is the
genomic architecture of multivariate phenotypes in natural
populations? How do interactions between population
structure, gene flow, and divergent natural selection shape
genomic architecture to facilitate rapid evolution? How many
directions in phenotypic space are available to evolution?
How wrong are the traditional quantitative genetic assumptions
about the structure of continuous phenotypic variation, and what
is a better model? We are using several empirical systems,
from fish to yeast, to address these questions.
Evolutionary genomic approaches have powerful applications to
conservation of species and ecosystems. We are collaborating
with a number of researchers to improve techniques for developing
large sets of genetic markers, assess phylogeographic structure,
detect hybridization and introgression, and estimate patterns of
genetic variation in natural populations.
Cancer as an Evolutionary Process
The cell lineages in a developing tumor form a highly
heterogeneous, evolving population, and prognosis and treatment
options depend on this evolutionary process. We are seeking
to combine evolutionary genomic theory and high-throughput
sequencing to understand evolution in cancer at the genomic scale.
Allendorf, University of Montana
Arnold, Oregon State University
Bill Cresko, University of
Funk, Colorado State University
Brian Langerhans, North
Carolina State University
Luikart, University of Montana
Barry Williams, Michigan
Center for Evolution
and Cancer, University of California San Francisco
For research support, thanks to:
for the Study of Evolution in Action